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KMID : 0370219840280030169
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Yakhak Hoeji
1984 Volume.28 No. 3 p.169 ~ p.177
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Effect of Diethylphthalate on the Release of Salicylic Acid from Ethylcellulose Films
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이승룡/Lee SY
신상철/이민화/심창구/Shin SC/Lee MH/Shim CK
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Abstract
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Release characteristics of salicylic acid from ethylcellulose(EC) films containing varying ratio of dieththylphthalate (DEP) were studied. Mathematical analysis of the release data showed that the release behavior actually conforms with the Higuchi’’s diffusion-controlled model. The release rate constants(k) were independent from the film thickness and the pH of release medium, but were proportional to the concentration of salicylic acid itself. The logarithm of the release rate constant (log k) increased as the concentration of DEP was increased. In conclusion, hydrophobic plastisizer DEP seemed to be very useful in controlling release rate constant of slightly soluble drugs as like salicylic acid without changing it’s release characteristics.
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